Key Dates

30 June 2014

On site registration opens

Further key dates

The Axon Initial Segment, a plastic gatekeeper for neuronal activity

Date & Venue

14.00 - 16.00

The axon initial segment (AIS) is a strategic place for neurons. It is there that nerve impulses are generated. Our session will review the molecular composition and the AIS and clarify the cellular mechanisms responsible for assembly and maintenance of the AIS in normal health, and during disease or injury. We will demonstrate that the AIS is a plastic structure that adapts to changes in the environment by dramatic reorganization or more subtle modulation occurring on timescales ranging from days to seconds.

Jean-Francois Perrier
University of Copenhagen
Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation
14.00 - 14.30
Jean-Francois Perrier
University of Copenhagen
Activity-dependent plasticity of the axon initial segment and its synapses
14.30 - 14.45
Juan Burrone
Kings College London
United Kingdom
Molecular processes involved in the plasticity of the axon initial segment
14.45 - 15.15
Benedicte Dargent
CNRS-Aix Marseille University
Neuromodulation of action potential initiation
15.15 - 15.30
Kevin Bender
University of California, San Francisco
United States
Tuning electrotonic coupling of axonal and dendritic trees
15.30 - 16.00
Maarten Kole
Netherlands Institute for Neuroscience